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KMID : 0895420070170010001
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Journal of Korean Society of Occupational and Enviromental Hygiene
2007 Volume.17 No. 1 p.1 ~ p.12
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Critical Review on Relationship between Exposure to Metalworking Fluids and Non-malignant Respiratory Diseases
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Park Dong-Uk
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Abstract
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We have reviewed all cases and epidemiological studies that have reported the association between worker’s exposure to metalworking fluids(MWF) and non-malignant respiratory diseases. The followings are main conclusions we critically reviewed. Exposure to MWF was believed to be significantly related to the risk of cough and phlegm. Relative risk caused by straight MWF was found to be higher in exposure to straight MWF than water-soluble MWF. We also found that exposure to water-soluble MWF significantly caused hypersensitivity pneumonitis (HP) and occupational asthma. The main culprits that cause the development of HP and asthma are believed to be microbes contaminated in MWF, ethanolamine and biocides. HP and asthma could be developed at even exposure to lower than 0.5 ㎎/㎥, exposure level recommended by NIOSH. Most epidemiological studies have reported that relationship between chronic bronchitis and exposure to MWF was significant. Although there were several studies that suggested the significant association between exposure to MWF and the development of rhinitis and sinusitis, we could not conclude the causal relationship because of lack of evidences
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KEYWORD
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metalworking fluids, MWF, non-malignant respiratory diseases, HP, occupational asthma, chronic bronchitis, rhinitis, sinusitis
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